Serotonin (5-Hydroxytryptamine)

Abstract

Serotonin is reviewed under these heads: history, isolation, enteramine, question of multiple serum vasoconstrictors, possible metabolic pathways, enzymatic destruction, assay, distribution, pharmacology of partially purified serum vasoconstrictor, pharmacology of synthetic and natural serotonin, modification of vascular responses to serotonin by drugs (antimetabolites, dibenamine, d-lysergic acid diethylamide, antihistamines, ergotamine, adrenergic blocking agents, yohim-bine, 1-hydrazinophthalazine, local anesthetics), miscellaneous effects, origin, and functional significance.