Low Expression of the Apolipoprotein B mRNA–Editing Transgene in Mice Reduces LDL Levels but Does Not Cause Liver Dysplasia or Tumors
Open Access
- 1 June 1998
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 18 (6), 1013-1020
- https://doi.org/10.1161/01.atv.18.6.1013
Abstract
—Hepatic expression of apolipoprotein (apo) B mRNA–editing enzyme catalytic polypeptide 1 (APOBEC-1) has been proposed as a gene therapy approach for lowering plasma low density lipoprotein...Keywords
This publication has 29 references indexed in Scilit:
- Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.JCI Insight, 1997
- Hepatic Expression of the Catalytic Subunit of the Apolipoprotein B mRNA Editing Enzyme (apobec-1) Ameliorates Hypercholesterolemia in LDL Receptor-Deficient RabbitsHuman Gene Therapy, 1996
- Hyperediting of Multiple Cytidines of Apolipoprotein B mRNA by APOBEC-1 Requires Auxiliary Protein(s) but Not a Mooring Sequence MotifPublished by Elsevier ,1996
- Overexpression of APOBEC-1 Results in Mooring Sequence-dependent Promiscuous RNA EditingPublished by Elsevier ,1996
- Gene Transfer of Cytidine Deaminase apoBEC-1 Lowers Lipoprotein(a) in Transgenic Mice and Induces Apolipoprotein B Editing in RabbitsHuman Gene Therapy, 1996
- Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.JCI Insight, 1995
- The Mechanism for Apo-B mRNA Editing Is DeaminationBiochemical and Biophysical Research Communications, 1993
- Molecular Cloning of an Apolipoprotein B Messenger RNA Editing ProteinScience, 1993
- Remnants of lipoproteins of intestinal and hepatic origin in familial dysbetalipoproteinemia.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1983
- Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteinsBiochemistry, 1978