Hemolytic-Uremic Syndrome in Two Siblings

Abstract
RECENT reviews1 , 3 do not mention the hemolytic-uremic syndrome of children in siblings except for the fatal outcome in six-month-old, hyperlipemic monozygotic twins.3 We encountered this syndrome in siblings. One died of uremia after repeated episodes. The other recovered completely after one episode.Case 1. An 8-month-old girl seen in June. 1949. had had fever and dark urine for 2 days. Physical examination showed only fever. Laboratory findings included anemia. increased blood urea. proteinuria and erythrocyturia. A blood smear disclosed anisocytosis poikilocytosis and burr cells. She subsequently had similar episodes and died of azotemia, hypertension and anuria in 1957. Histologic find . . .

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