Stimulation of ACTH-Release in Humans by Non-Pressor Fraction from Commercial Extracts of Posterior Pituitary.

Abstract
A non-pressor material separated from proto-pituitrin by chromatography and known to stimulate release of ACTH in vitro stimulated the release of ACTH in human subjects as evidenced by measurements of plasma 17-hydroxycorticosteroid concentrations. This effect was obtained in the absence of significant side-effects.