Aromatization of Testosterone by Adipose Tissue and Sexual Behavior of Castrated Male Rats
Open Access
- 1 November 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 27 (4), 765-770
- https://doi.org/10.1095/biolreprod27.4.765
Abstract
The influence of aromatization of testosterone occurring in adipose tissue has been studied in castrated obese male rats. The treatment for 30 days with a subliminal dose (115 μg/kg per day) of testosterone propionate improved significantly the sexual performance of castrated obese male rats as compared to the nonobese controls. Untreated castrated obese animals did not show any enhancement of sexual behavior. Furthermore, obesity failed to improve sexual performance in intact male rats. Measurements of plasma levels of testosterone and 17β-estradiol showed an increase in aromatization of testosterone in obese rats. Present data suggest that adipose tissue can be considered an important site for aromatization of testosterone to 17β-estradiol, and that aromatization is involved in the activation of sexual behavior in castrated male rats.This publication has 14 references indexed in Scilit:
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