Opiate-like, naloxone-reversible effects of androsterone sulfate in rats
- 1 December 1978
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 56 (6), 940-944
- https://doi.org/10.1139/y78-149
Abstract
Androsterone sulfate (5α-androstan-3α-ol-17-one, 3-sodium sulfate) administered to freely moving rats via cerebroventricular cannulae induced analgesia, wet-dog shakes, body jerks, rigidity, Straub tail, hypermotility, excessive grooming, hyperreactivity to stimuli, aggression, escape behavior, EEG spiking, and behavioral and EEG seizures. These responses resemble those produced by certain opiate drugs and by beta-endorphin, an endogenous peptide; they appear during the 5-min infusion period, persist in some cases for several hours, and are diminished by pretreatment with the narcotic antagonist naloxone. These findings indicate that steroid hormones can act upon at least some of the same central pathways influenced by recognized opiate compounds.This publication has 8 references indexed in Scilit:
- Opiate-like naloxone-reversible actions of somatostatin given intracerebrallyCanadian Journal of Physiology and Pharmacology, 1978
- Morphine and Enkephalin: Analgesic and Epileptic PropertiesScience, 1977
- Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental IllnessScience, 1976
- Dehydroepiandrosterone sulfate in plasma: hydrolysis, extraction and radioimmunoassaySteroids, 1976
- Somatostatin and ACTH are peptides with partial antagonist-like selectivity for opiate receptorsEuropean Journal of Pharmacology, 1976
- Cortical administration of somatostatin (SRIF): Effect on sleep and motor behaviorPharmacology Biochemistry and Behavior, 1976
- Radioimmunoassay of androsterone and androsterone-3-sulfate in plasmaSteroids, 1976
- Analgesia and hyperreactivity following morphine microinjection into mouse brainPharmacology Biochemistry and Behavior, 1976