Comparison of Monoamine Oxidase Inhibitory Effects of Iproniazid and Its Phenyl Congener.
- 1 December 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 99 (3), 617-619
- https://doi.org/10.3181/00379727-99-24438
Abstract
Comparison of monoamine oxidase (MAO) inhibiting properties of iproniazid and its phenyl congener, l-isonicotinyl-2-phenylisopropylhydrazine showed the latter to be 1.5 to 2 times as effective in inhibiting MAO both in vitro and in vivo. The addition of a phenyl group to the isopropyl chain of iproniazid enhances MAO inhibitory properties. Comparisons with beta-phenyl-isopropylhydrazine also indicate that the isonicotinyl group hinders the MAO inhibiting property of the former compound.Keywords
This publication has 6 references indexed in Scilit:
- BETA-PHENYLISOPROPYLHDRAZINE, A POTENT AND LONG ACTING MONOAMINE OXIDASE INHIBITOR1958
- The mechanism of the irreversible inhibition of rat liver monoamine oxidase by iproniazid (Marsilid)Biochemical Journal, 1957
- THE ESTIMATION OF 5-HYDROXYTRYPTAMINE (SEROTONIN) IN BIOLOGICAL TISSUESJournal of Biological Chemistry, 1955
- Metabolism of 5-Hydroxytryptamine (Serotonin) by Monoamine Oxidase.Experimental Biology and Medicine, 1955
- In vivo Inhibition of Monoamine Oxidase Studied with Radioactive TyramineExperimental Biology and Medicine, 1953
- In vivo Inhibition of Liver and Brain Monoamine Oxidase by 1-Isonicotinyl-2-Isopropyl Hydrazine.Experimental Biology and Medicine, 1952