Use of Commonly Prescribed Antibiotics Is Not Associated with Prevalence ofHelicobacter pyloriInfection in Adults
- 1 January 1997
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 32 (11), 1096-1099
- https://doi.org/10.3109/00365529709002987
Abstract
Background: The aim of the study was to investigate the association of the use of commonly prescribed antibiotics with prevalence of Helicobacter pylori infection in a population of adult outpatients. Methods: All patients aged 15–79 years who visited the practice of a general practitioner (GP) between June and September 1996 in a suburban community near Ulm, a city in southern Germany, were asked to participate in the study. Infection status was determined with a l3C-urea breath test. In addition, the patients were asked to fill out a self-administered questionnaire. Results: Overall, 475 outpatients were included in the study (response, 94.1%). A total of 266 patients (56.0%) reported a history of antibiotic treatment within the past 5 years, whereas 147 patients (30.9%) did not (62 patients (13.1%) did not know). Prevalence of infection in patients with a history of antibiotic medication during the past 5 years was 23.3%, whereas the prevalence of infection was 20.4% in subjects without antibiotic treatment (P = 0.283 after stratification for age). Control for other potential confounders by multivariable analysis did not materially alter the results. Conclusion: Coincidental antibiotic treatment is not associated with H. pylori prevalence in adults.Keywords
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