Use of Flumethiazide as an Adjunct to the Therapy of Hypertension

Abstract

SINCE the "second look" at diuretic agents has revealed them to possess antihypertensive properties, a number of agents have been studied for this pharmacologic attribute.^{1 , 2} The latest compound to appear on the diuretic scene is flumethiazide¶ (6-[trifluoromethyl]-1,4,2-benzothiadiazine-7-sulfonamide, 1,1 -dioxide). The clinical pharmacology³ and the use of the drug in the treatment of edematous states of varied etiology⁴ have previously been studied. These results indicate that flumethiazide has a potency as a diuretic agent that is not significantly different from that of chlorothiazide. Furthermore, the drug is repetitively effective after oral administration — that is, tolerance to the compound does not . . .