The butyrophenone derivative methylperone (Buronil) reduced motor intention and drive (physiological acceleration transducer) experimentally; it also reduced emotional tension as shown by the galvanic skin reflex and reactivity as shown by multigraph recording; it diminished general cerebral stimulation (critical flicker fusion frequency); in the EEG it produced relaxation while leaving arousal activity intact. Clinically, it produces optimum sedation in senile confusion states. In agitated depression, methylperone was found adequately anxiolytic in combination with amitriptyline, affording a subjective relief of tension and anxiety during the phase before onset of the antidepressant effect.