EVIDENCE FOR BALANCING SELECTION AT HLA
Open Access
- 1 July 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 104 (3), 449-456
- https://doi.org/10.1093/genetics/104.3.449
Abstract
HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.This publication has 13 references indexed in Scilit:
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