Tropical Sprue and Vitamin B12

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Abstract
THE entire small intestine is involved in maintenance of normal erythropoiesis and in the prevention of megaloblastic anemia. The proximal small bowel is involved in absorption and maintenance of an adequate supply of folic acid,1 whereas the distal portion is essential for absorption of vitamin B12.2 , 3 Interference with absorption of either substance may lead to the development of megaloblastic anemia. Tropical sprue is one of many diseases in which abnormal intestinal function may precipitate anemia. Usually, this anemia has been attributed to a deficiency of folic acid, but sprue is a disease in which the entire small bowel . . .