Incompatibility between Sulfamethizole and Methenamine Mandelate

Abstract

MARKED turbidity was noted in the urine of 9 of 32 patients during the clinical trial of a preparation containing methenamine mandelate and sulfamethizole.* This trial had been initiated in an attempt to duplicate the outstanding therapeutic response reported¹ to occur with the use of this preparation in patients with resistant urinary-tract infections. Turbidity of the urine, which varied from a mild cloudiness to "buttermilk" flocculency, was referred to in the original report and, although disturbing to the patient, was cited as having no apparent adverse effect on the outcome of therapy. The reaction appeared to be related to pH, . . .