Inhibitors of the dicarboxylate and tricarboxylate transporting systems of rat liver mitochondria

Abstract
A large number of compounds were tested for their effectiveness as inhibitors of the tricarboxylate and dicarboxylate transporting systems of rat liver mitochondria as monitored by citrate/[14C] citrate exchange and phosphate/[14C]l-malate exchange, respectively. The influence of inhibitor structure on inhibitory potency is discussed for each transporting system and deductions made concerning the nature of the binding sites of these carrier systems.

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