Role ofNramp1Deletion inChlamydiaInfection in Mice

Abstract

Elicited macrophages from 129sv mice with a functional deletion of the natural-resistance-associated macrophage protein 1 gene (Nramp1) were shown to be as susceptible as wild-type mice to infection with theChlamydia trachomatismouse pneumonitis and L3 serovars and toChlamydia pneumoniae. Furthermore, the two groups of mice were shown to be similarly susceptible to an intranasal infection with these microorganisms. In conclusion, theNramp1gene does not appear to play a major role in the regulation of the susceptibility of mice to a chlamydial infection.