Cancer Induction After Pyloroplasty in Rats
- 1 June 1982
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 117 (6), 768-771
- https://doi.org/10.1001/archsurg.1982.01380300016005
Abstract
• Nineteen male Wistar rats received N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) in drinking water (83 mg/L) to initiate glandular adenocarcinoma of the stomach; eight control rats received tap water. After 12 weeks a pyloroplasty was performed on nine rats receiving MNNG and three control rats. Ten MNNG-treated rats and five control rats had no operation. All were observed for 38 weeks before being killed. No difference in the incidence of antral adenocarcinomas was found between the MNNG-treated groups; however, those without operation showed in situ changes in the duodenum and those treated with pyloroplasty showed five invasive adenocarcinomas. In this model pyloroplasty alone did not increase the risk of gastric cancer but increased the risk of duodenal tumors. Pyloroplasty apparently accelerated the gastric evacuation rate, resulting in greater insult to the duodenal mucosa. Such a condition may require a higher proliferative rate in the duodenum and may increase subsequent formation of malignant tumors. (Arch Surg 1982;117:768-771)This publication has 9 references indexed in Scilit:
- Diversion of Duodenal ContentsArchives of Surgery, 1980
- Gastric carcinoma after treatment of ulcerThe American Journal of Surgery, 1980
- Gastric remnant carcinomaCancer, 1979
- ENHANCEMENT OF GASTRIC CARCINOGENESIS IN DOGS GIVEN N-METHYL-N'-NITRO-N-NITROSOGUANIDINE FOLLOWING VAGOTOMY1979
- Carcinoma and Possible Precancerous Changes of the Gastric Stump After Billroth II ResectionGastroenterology, 1977
- Pattern of Gastric Emptying after Vagotomy and PyloroplastyBMJ, 1973
- The effect of vagotomy on human gastric secretionBritish Journal of Surgery, 1970
- Vagotomy, Gastroenterostomy and Experimental Gastric CancerArchives of Surgery, 1968