Über die Eignung des Plaque-Testes zur Analyse der Virusvermehrung in Zellkulturen

Abstract

The results of three experiments described confirm the correctness of the working hypothesis that, in the model used, under proper conditions a rapid plaque formation indicates a strong virus multiplication, a slow plaque formation a weak virus multiplication. Hence, in this case, the size of the plaques can be used as a measure of the intensity of virus multiplication in the cells of a culture. It is to be expected that other factors concerned in plaque formation can be analyzed by means of this method.