Autotomy following nerve injury: Genetic factors in the development of chronic pain

Abstract

Several weeks following transection and ligation of the hind limb nerves in rats, the animals often attack their anesthetic foot (autotomy). This behavior is thought to reflect a sensory pathology analogous to anesthesia dolorosa. The extent of autotomy varies greatly in genetically different populations of rats. Rats of 1 population, LC2, showed high autotomy levels; rats of another, LC1, showed very low autotomy levels. The main genetic difference between these 2 populations is the presence of inbred Lewis rat stock in the LC1 population. Pure Lewis strain rats proved to have very low autotomy levels. Constitutional differences between different rat populations affect the extent of autotomy. After seemingly identical nerve injuries, some humans develop chronic pain syndromes and others do not. Rat strains may provide a model for investigating the physiological basis of constitutional susceptibility to chronic pain.