Differential requirements for the induction of interleukin 2 responsiveness in L3T4+ and Lyt-2+ T cell subsets.
Open Access
- 1 November 1985
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 162 (5), 1738-1743
- https://doi.org/10.1084/jem.162.5.1738
Abstract
Minimal requirements for the induction of interleukin 2 (IL-2) responsiveness in purified subsets of murine T lymphocytes have been investigated. Whereas Lyt-2+ cells could be induced to IL-2-dependent growth by lectin, phorbol ester, or calcium ionophore, none of these stimuli was by itself sufficient for L3T4+ nations of lectin plus phorbol ester or or ionophore plus phorbol ester (but not Lyt-2+ cells) was independent of accessory cells and cell-cell contact.Keywords
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