The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae
- 20 October 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (26), 6254-6258
- https://doi.org/10.1016/j.febslet.2006.10.029
Abstract
OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as α‐KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K+ channels (vertebrate Kv1.1‐Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183 ± 3 nM but did not affect any of the other channels.Keywords
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