High accumulation of 2,3,4,7,8-pentachlorodibenzofuran to hepatic microsomes of rats.
- 1 January 1984
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 7 (6), 414-419
- https://doi.org/10.1248/bpb1978.7.414
Abstract
The tissue and subcellular distributions of 14C-2,3,4,7,8-pentachlorodibenzofuran (PenCDF), 1 of the most important causal agents of Yusho [outbreak which occurred in Japan in 1968, due to contaminated rice oil] were studied using rats. More than 60% of the radioactivity given orally was accumulated in the liver after 5 days and this high percentage persisted over a period of 3 wk. Subcellular fractionation of the liver homogenate showed unusual separation by PenCDF-pretreatment, but the distribution of radioactivity was just parallel to those of cytochrome P-450 content and G-6-P (EC 3.1.3.9) activity. Gas chromatographic analysis provided evidence that the extracts from the liver and its subcellular fractionations contained only unchanged PenCDF. PenCDF has some affinity to endoplasmic reticulum of rat liver.This publication has 5 references indexed in Scilit:
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