EFFERENT CONNEXIONS OF THE HUMAN PREFRONTAL REGION WITH REFERENCE TO FRONTO-GYPOTHALAMIC PATHWAYS

Abstract
The Glees silver impregnation method was used to study a case of topectomy of area 10/FE for contrast with a case of rostral leucotomy which had been aimed at undercutting areas 9/FDm and 10/FE. Fiber systems arising from the extreme frontal pole are (1) a distinct projection to the dorso-medial thalamic nucleus; (2) short association fibers to adjacent prefrontal cortex; (3) a few callosal fibers and (4) a weak contribution to the superior longitudinal fasciculus. A pathway originates anterior to the agranular frontal cortex and terminates in the ventro-medial and lateral hypothalamic nuclei.
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