Effect on Tumor Homografts of Treating Hosts with Antiproteolytic Enzyme Compounds.
- 1 April 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 112 (4), 964-966
- https://doi.org/10.3181/00379727-112-28222
Abstract
Summary Two compounds, EACA and SBTI, known suppressors of certain proteolytic enzymes, were administered daily to mice that had been inoculated with a tumor that they normally reject. Nearly half of all the Strain A and C-57Bl mice treated with either agent developed large tumors within 12 days. No tumor growth was seen in any of the untreated control animals. Of the 18 mice given combined doses of both compounds, 15 developed sizable tumors. The tumors always reached a maximum size and then regressed. Therefore, it seems that proteolytic enzymes participate in the rejection of homotransplanted tumors, but that suppressing their effect merely attenuates the immune response, and other mechanisms eventually cause the demise of the tissue.Keywords
This publication has 1 reference indexed in Scilit:
- Regional lymph node response to skin grafts between strains of mice differing by strong and weak histocompatibility genesJournal of Surgical Research, 1961