Norepinephrine-Sensitive Adenylate Cyclases in Rat Brain: Relation to Behavior and Tyrosine Hydroxylase
- 12 April 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 184 (4133), 175-177
- https://doi.org/10.1126/science.184.4133.175
Abstract
Responses of norepiniephrine sensitive adeniosinie 3',5'-monophosphate (cyclic AMP)-generating systems in combined midbrain-striatal slices of four rat strains correlate positively with spontaneous behavioral activity and negatively with levels of midbrain and striatal tyrosine hydroxylase. Responses of cerebral cortical norepinephrine-sensitive cyclic AMP systems correlate negatively with spontaneous behavioral activity antd positively with midbrain and striatal tyrosine hydroxylase. Such correlations were not found with responses of the cyclic AMP- generatinlg systems to isoproterenol, adenosine. veratridine or of an adenosne and norepinephrine combination.Keywords
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