Cloning and sequencing of glutamate mutase component S from Clostridium tetanomorphum Homologies with other cobalamin‐dependent enzymes
- 28 September 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 310 (2), 167-170
- https://doi.org/10.1016/0014-5793(92)81321-c
Abstract
The gene encoding component S, the small subunit1 of glutamate mutase, an adenosylcobalamin (coenzyme B12)-dependent enzyme from Clostridium tetanomorphum has been cloned and its nucleotide sequence determined. The mutS gene encodes a protein of 137 amino acid residues, with M r, 14,748. The deduced amino acid sequence showed homology with the C-terminal portion of adenosylcobalamin-dependent methylmalonyl-CoA mutase [1989, Biochem. J. 260, 343–352] and a region of cobalamin-dependent methionine synthase which has been shown to bind cobalamin [1989, J. Biol. Chem 264, 13888–13895].Keywords
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