Carcinogenesis: changes in the properties of some rat-liver proteins after administration of 4-dimethylamino-3′-methylazobenzene

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Abstract
Soluble rat-liver proteins were fractionated in sequence by anion- and cation-exchange chromatography and by starch-gel electrophoresis. A fraction corresponding to the so-called "slow-moving proteins" was resolved into 8 components. Only one of these components contained covalently bound azo dye when the carcinogen 4-dimenthylamino-3[image]-methylazobenzene was fed to the animals shortly before they were killed. The properties of another component were found to have changed as a result of feeding with the dye.