Roles of vagal afferents on discharge patterns and CO2-respon-siveness of efferent superior laryngeal, hypoglossal, and phrenic respiratory activities in anesthetized rats.

Abstract

Discharge patterns and CO2-responsiveness of the efferent respiratory activities in the superior laryngeal (Xsl), hypoglossal (XII) and phrenic (Phr) nerves were compared between vagi-intact and denervated rats. Bilateral cervical vagotomy decreased the respiratory frequency (f), minute Phr activity (peak integrated Phr activity .times. f) and consequently elevated end-tidal CO2 partial pressure (PETCO2). Augmentation of the peak inspiratory activity following vagotomy was much larger in the Xsl and XII nerves than that in the Phr nerve. After vagotomy, the time delay from the onset of inspiratory activities in the Xsl or XII nerve to the onset of the Phr bursts was greatly prolonged. While in the vagi-intact rats the peak inspiratory activities of these cranial nerves were not increased in response to elevated PETCO2, the activities, in particular of the XII nerve, were augmented by high PETCO2 in the absence of vagal afferents. The vagal afferents apparently inhibit phasic Phr discharges and inspiratory output neurons in the Xsl or XII motor nuclei being activated in normo- and hypercapnia. They facilitate temporally the onset and progress of inspiratory activities in various groups of respiratory output neurons.