Distemper and Measles Viruses. I. Lack of Immunogenic Crossing in Dogs and Chickens.

Abstract

Puppies vaccinated against canine distemper (CD) or immunized and challenged with CDvirus developed high levels of homologous antibodies but failed to develop complement-fixing or serum neutralizing antibodies for measles virus (MV). Similarly, chickens hyperimmunized with CD virus did not develop measles neutralizing antibodies, although CD antibodies in appreciable levels appeared in 6 of 6 birds. Hyperimmunization of another group of chickens with MV was followed by no neutralizing CD antibodies in any of 6, whereas 5 of 6 birds gave a substantial measles response.