A TRANSFORMING GENE, HST, FOUND IN NIH 3T3 CELLS TRANSFORMED WITH DNA FROM 3 STOMACH CANCERS AND A COLON CANCER

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  • 1 April 1987
    • journal article
    • research article
    • Vol. 78 (4), 325-328
Abstract
DNA samples from 5 out of 15 stomach cancers and from 5 out of 15 colon cancers showed transforming activity in NIH 3T3 cells upon transfection. A transforming gene from an NIH 3T3 transformant induced by transfection of DNA from a stomach cancer was cloned, and showed transforming activity amounting to 120 focus-forming units/.mu.g. The transforming gene was identified as hst. The hst gene was also responsible for acquisition of the transforming activity in DNA samples from 2 other stomach cancers and one colon cancer.