Diverse Causes of Hypoglycemia-Associated Autonomic Failure in Diabetes
Top Cited Papers
- 27 May 2004
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 350 (22), 2272-2279
- https://doi.org/10.1056/nejmra031354
Abstract
This review explains our current understanding of the syndromes of defective glucose counterregulation and hypoglycemia unawareness in persons with diabetes. The physiologic defenses against hypoglycemia — the glucagon and epinephrine responses — are compromised in most people with type 1 diabetes and in many with advanced type 2 diabetes. In addition to hypoglycemia, exercise and sleep are causes of autonomic failure that must be recognized and require changes in the management of diabetes.This publication has 48 references indexed in Scilit:
- Hypoglycemia in DiabetesDiabetes Care, 2003
- Glucokinase Is the Likely Mediator of Glucosensing in Both Glucose-Excited and Glucose-Inhibited Central NeuronsDiabetes, 2002
- Hypoglycaemia: The limiting factor in the glycaemic management of Type I and Type II Diabetes*Diabetologia, 2002
- Hypoglycemia-Associated Autonomic Failure in Advanced Type 2 DiabetesDiabetes, 2002
- Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type 1 diabetes.Diabetes, 1998
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 1998
- Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)The Lancet, 1998
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1993
- Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia.Journal of Clinical Investigation, 1993
- Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM. A vicious cycleDiabetes, 1992