EFFECT OF ALPHA-DIFLUOROMETHYL ORNITHINE ON THE TRANSPLANTABLE RAT HEPATOMA 5123, 1-1
- 1 January 1980
- journal article
- research article
- Vol. 30 (2), 377-380
Abstract
Oral treatment with .alpha.-difluoromethyl ornithine (2.75 g/kg rat per day) simultaneous with subscapular implantation in Buffalo rats of [rat] 5213, 1-1 hepatoma cells, retarded significantly the tumor growth rate for 20 days. The regimen decreased tumor ornithine decarboxylase activity (ODC). The tumors growing despite treatment maintained their malignant characteristics and ODC activity when retransplanted into normal animals.This publication has 4 references indexed in Scilit:
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