Synthesis of some new S-alkylated derivatives of 5-mercapto-2'-deoxyuridine as potential antiviral agents
- 1 May 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (5), 569-572
- https://doi.org/10.1021/jm00179a019
Abstract
A series of S-alkylated derivatives of 5-mercapto-2''-deoxyuridine was prepared by alkylation of the preformed nucleoside. Two of these compounds, the S-propargyl and S-allyl derivatives, showed significant antiviral activity against herpes simplex type 1 in [human cervical carcinoma] HeLa TK- cells but appear to be less effective in this assay system than some previously reported 5-substituted 2''-deoxyuridines.This publication has 5 references indexed in Scilit:
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