Modification of the 5' position of purine nucleosides. 1. Synthesis and biological properties of alkyl adenosine-5'-carboxylates

Abstract

A series of esters of adenosine-5''-carboxylic acid were prepared. Most of the compounds were nontoxic, causing prolonged increases in coronary sinus PO2 [O2 tension] when administered to anesthetized dogs; the ethyl ester was most active. Nitrosation and oxidation of the ethyl ester gave, respectively, inactive inosine ethyl ester and the fairly active N1-oxide ethyl ester.