ANTIGENICITY OF HUMAN CHORIONIC GONADOTROPHIN
- 1 January 1961
- journal article
- research article
- Vol. 4 (1), 1-+
Abstract
Human chorionic gonadotrophin (HCG) is antigenic in rabbits when injected with Freund''s adjuvant. The HCG used for immunization showed the presence of five antigens in the Ouchterlony plates against the homologous antiserum. Three of these antigens were common to human serum and one of these three of normal human urine. Rabbit antiserum to HCG absorbed with human serum did not form any antigen-antibody precipitin line with either normal human serum or normal human urine. It formed two precipitin lines with HCG. One ml of the rabbit antiserum to HCG could inhibit 150 I.U. of HCG as tested by the Aschheim-Zondek test in mice and ovarian hyperaemia test in rats. The absorbed antiserum could inhibit hormonal activity of HCG even when the antiserum and HCG were injected simultaneously at separate sites.Keywords
This publication has 9 references indexed in Scilit:
- Immunochemical Investigations of Human Pituitary Growth HormoneJournal of Biological Chemistry, 1960
- Localization of tissue antigens with the fluorescent antibody technique: application to human anterior pituitary hormones.1958
- Antigenicity of insulin: diabetes induced by specific antibodiesBiochemical Journal, 1955
- MICROMETHODS FOR THE STUDY OF PROTEINS AND ANTIBODIES .1. PROCEDURE AND GENERAL APPLICATIONS OF HEMAGGLUTINATION AND HEMAGGLUTINATION-INHIBITION REACTIONS WITH TANNIC ACID AND PROTEIN-TREATED RED BLOOD CELLS1954
- THE ADSORPTION OF PROTEINS ON ERYTHROCYTES TREATED WITH TANNIC ACID AND SUBSEQUENT HEMAGGLUTINATION BY ANTIPROTEIN SERAThe Journal of Experimental Medicine, 1951
- Antigen — Antibody Reactions In GelsActa Pathologica Microbiologica Scandinavica, 1949
- ANTIHORMONE FORMATION DURING CHORIONIC GONADOTROPIN THERAPYJournal of Clinical Endocrinology & Metabolism, 1949
- SELECTIVE NEUTRALIZATION OF THE FOLLICLESTIMULATING ACTION OF GONADOTROPIC PREPARATIONS BY ANTIGONADOTROPIC SERA1Endocrinology, 1941
- DOES THE GONADOTROPIC HORMONE INDUCE ANTIBODIES OR ANTIHORMONES?The Journal of Experimental Medicine, 1937