Renal excretion of cephapirin and cephaloridine: Evidence for saturable tubular reabsorption
- 1 June 1979
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 25 (6), 870-876
- https://doi.org/10.1002/cpt1979256870
Abstract
Drug concentrations in plasma and urine were determined in 5 healthy subjects after intravenous infusion of 1 gm cephapirin and cephaloridine. Sampling of blood and urine was frequent and prolonged. Specimens were analyzed by high-pressure liquid chromatography (HPLC). Renal clearance of cephapirin decreased to less than 5% of control in all subjects when drug concentrations in plasma and urine declined. Cephaloridine clearance decreased to a lesser extent. Our findings suggest that, besides tubular secretion and glomerular filtration, a saturable and probably active tubular reabsorption is also involved in the renal handling of these two cephalosporins. The saturable reabsorption process was characterized by its Michaelis-Menten constant Km and its maximum transport capacity Tm.This publication has 3 references indexed in Scilit:
- Quantitation of Antibiotics by High-Pressure Liquid Chromatography: CephalothinAntimicrobial Agents and Chemotherapy, 1978
- Renal handling of gentamicin and other antibiotics by the isolated perfused rat kidney: mechanism of nephrotoxicityJournal of Antimicrobial Chemotherapy, 1977
- Renal clearance and tissue accumulation of gentamicinClinical Pharmacology & Therapeutics, 1977