Genetic perturbations that reveal tertiary conformation of tRNA precursor molecules
- 1 September 1975
- journal article
- Published by Springer Nature in Nature
- Vol. 257 (5522), 106-110
- https://doi.org/10.1038/257106a0
Abstract
The ubiquity of tRNA-like conformations in tRNA precursors of prokaryotes provides a common structural basis for precursor recognition by the maturation enzymes. This design eliminates need for multiple enzymes to achieve the maturation of different precursors. Moreover, the requirement of this specific conformation for maturation guards against the production of potentially deleterious mutant tRNAs.Keywords
This publication has 15 references indexed in Scilit:
- A mutant of escherichia coli defective in removing 3′ terminal nucleotides from some transfer RNA precursor moleculesCell, 1975
- The nucleotide sequence of the dimeric precursor to glutamine and leucine transfer RNAs coded by bacteriophage T4Journal of Molecular Biology, 1975
- Nucleotide alterations in the bacteriophage T4 glutamine transfer RNA that affect ochre suppressor activityJournal of Molecular Biology, 1974
- Transfer RNA Biosynthesis: The Nucleotide Sequence of a Precursor to Serine and Proline Transfer RNAsProceedings of the National Academy of Sciences, 1974
- The psu1+ amber suppressor gene of bacteriophage T4: Identification of its amino acid and transfer RNAJournal of Molecular Biology, 1973
- Structural Studies on a Tyrosine tRNA PrecursorNature New Biology, 1973
- Identification of tRNA Precursor Molecules made by Phage T4Nature New Biology, 1973
- Mutants of Escherichia coli Thermosensitive for the Synthesis of Transfer RNAProceedings of the National Academy of Sciences, 1973
- The distribution of modified nucleosides in transfer RNAsJournal of Theoretical Biology, 1973
- Minor Components in Transfer RNA: Their Characterization, Location, and FunctionProgress in Nucleic Acid Research and Molecular Biology, 1972