Abstract
When crossed, the Mesitas and Santa Marta strains, both belonging to the Transitional race of Drosophlla paulistorum, produce fertile female and some sterile male hybrids. A genetic analysis suggests that the sterility in this case is caused, chiefly if not exclusively, by interaction of the Y chromosome of one strain, with the cytoplasm of the other strain. If the Y and the cytoplasm come from the same strain, the male is fertile, while if their sources are different, the male is usually sterile.