The gene controlling the binding sites of Dolichos biflorus agglutinin, Dlb-1, is on chromosome 11 of the mouse

Abstract

SUMMARY: A locus, Dlb-1, controlling the binding of the lectin from Dolichos biflorus to the intestinal epithelium and vascular endothelium of mice has been located on chromosome 11, 3.1 ± 1.4 centimorgans proximal to Rex, using recombinant inbred strains and conventional backcrosses with three-point linkage tests.The two alleles so far discovered at this locus behave unusually. The Dlb-1^a allele causes binding to the vascular endothelium but not to the intestinal epithelium while Dlb-1^b induces the exact reciprocal binding pattern, and the heterozygote shows both patterns.