Vitamin A Deficiency Exacerbates Murine Lyme Arthritis

Abstract

Vitamin A deficiency predisposes the host for a strong inflammatory response, suggesting that it may foster susceptibility to diseases, such as Lyme arthritis, in which activated macrophage and inflammatory cytokine production are pathogenic. Infected mice had a rapid serum retinol decline that correlated with the onset of arthritis. The mice with the least retinol developed acute arthritis earlier and more severely than those with the highest retinol. Earlier and stronger interleukin (IL)12, interferon-y (lFN)-γ, and tumor necrosis factor responses were found in Borrelia burgdorferi-infected, vitamin A-deficient mice compared with controls. The spirochetes induced IFN-γ secretion from un primed cells, and retinoid addition in vitro inhibited IFN-γ synthesis. Vitamin A deficiency may exacerbate acute Lyme arthritis by enhancing an acute arthritogenic inflammatory response initiated by spirochete-driven IFN-γ secretion. Conversely, vitamin A may lessen acute Lyme arthritis pathology by blocking IFN-γ and IL-12 synthesis.