Abstract
A total of 10 institutionalized children were maintained on an additive-free diet for 2 wk, followed by 2 wk in which 2 high, consecutive doses of artificial food colors were administered orally in a placebo-masked, double-blind experimental design. Measures of short-term verbal learning, visuomotor skills and actometer measures of limb activity, together with behavioral rating scales completed by teachers and care staff, all indicated the absence of any adverse behavioral or cognitive effect.