Effects of oestradiol and levonorgestrel on lipoprotein lipids and postheparin plasma lipase activities in normolipoproteinaemic women
- 1 April 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 99 (4), 630-635
- https://doi.org/10.1530/acta.0.0990630
Abstract
The effects of estradiol and levo-norgestrel on plasma lipoprotein cholesterol (Chol) and triglyceride (Tg) levels and on postheparin plasma lipoprotein lipase (LPL) and hepatic lipase(HL) activity were studied in 52 normolipoproteinemic women. The androgen-derived progestin levo-norgestrel increased postheparin plasma hepatic lipase (PH-HL) activity and decreased plasma high-density lipoprotein (HDL) lipid concentrations in a manner opposite to that of estradiol. The relationships between PH-HL activity and HDL lipids suggest an important role for this enzyme as a mediator of sex hormone action on HDL.Keywords
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