Mice Naturally Resistant to Yersinia pestis Δ pgm Strains Commonly Used in Pathogenicity Studies
- 1 November 2006
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (11), 6501-6504
- https://doi.org/10.1128/iai.00597-06
Abstract
We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Δ pgm strains of Yersinia pestis ; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, these mice offer a powerful system in which to map in parallel host resistance traits and opposing bacterial virulence properties for plague.Keywords
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