Changes in Fatty Acid Composition in Liver Lipid Fractions of Pyridoxine-deficient Rats Fed Cholesterol
- 1 February 1966
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 88 (2), 193-201
- https://doi.org/10.1093/jn/88.2.193
Abstract
This study was made to determine whether changes in fatty acid patterns of liver phospholipids and sterol esters accompanied the decreases in esterified sterol previously observed in pyridoxine-deficient rats. The diets included: (a) basal casein-5% cottonseed oil-sucrose diet; (b) basal diet plus cholesterol; (c) basal diet plus taurocholate; (d) basal diet plus cholesterol and taurocholate. Cholesterol was added to exaggerate the need for oleate and arachidonate since this stress might provide added information on unsaturated fatty acid metabolism in pyridoxine deficiency. Taurocholate was added to increase cholesterol absorption. These diets, with or without pyridoxine, were fed to male weanling rats for 6 weeks. Food intake of controls was restricted to the food intake of the corresponding deficient groups. Phospholipid tended to be lower in the deficient groups and liver sterol ester was significantly lower. All deficient groups showed a significant decrease in oleate in all lipid fractions, compared with their respective controls. Arachidonate and linoleate were significantly higher in sterol esters in all deficient groups. It was concluded 1) that pyridoxine deficiency significantly alters the metabolism of dietary and endogenous cholesterol and 2) that decreases in monoenoic acids in pyridoxine deficiency may be related to insulin insufficiency.Keywords
This publication has 19 references indexed in Scilit:
- Sequential changes in liver and heart lipids after giving linoleate or linoleate plus pyridoxine to rats depleted of fat and pyridoxineBiochemical Journal, 1964
- COMPARATIVE EFFECTS OF PYRIDOXINE DEFICIENCY AND RESTRICTED FOOD INTAKE ON ACETATE-2-C14 INCORPORATION INTO RAT LIVER LIPIDSCanadian Journal of Biochemistry, 1964
- Carbohydrate and Fat Metabolism and Response to Insulin in Vitamin B6-deficient RatsJournal of Nutrition, 1964
- Analysis of fatty acid mixtures: Comparison of two “absolute” methods of determinationAnalytical Biochemistry, 1962
- Tissue Lipid Fatty Acid Composition in Pyridoxine-Deficient RatsJournal of Nutrition, 1961
- Effect of Pyridoxine Deficiency on Fatty Acid Composition of Carcass and Brain Lipids in the RatJournal of Nutrition, 1961
- Polyenoic Acid in Hypercholesterolæmia induced by Pyridoxine Deficiency in RatsNature, 1960
- RELATIONSHIP OF VITAMIN B6 TO GLUCONEOGENIC ACTION OF CORTISOL11Endocrinology, 1960
- Influence d'une carence en vitamine B6 sur la teneur en acides tauro-conjugués et glyco-conjugués de la bile du ratBiochimica et Biophysica Acta, 1956
- Polyethenoid fatty acid metabolism. VI. Effect of pyridoxine on essential fatty acid conversionsArchives of Biochemistry and Biophysics, 1952