The Discovery of an Enantioselective Receptor for (−)-Adenosine from a Racemic Dynamic Combinatorial Library
- 30 August 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (38), 12422-12423
- https://doi.org/10.1021/ja0647699
Abstract
The use of laser polarimetry detection coupled with HPLC is demonstrated to enable the discovery of enantioselective receptors from racemic dynamic combinatorial libraries. Templating with an enantiopure analyte, such as (−)-adenosine, leads to amplification of one enantiomer of the cyclic dimer. A result confirmed with a pseudo-racemic library wherein one of the enantiomers was d-labeled for mass spec analysis. The resulting dimer is thus an enantioselective receptor for (−)-adenosine.Keywords
This publication has 4 references indexed in Scilit:
- Metal-ion induced amplification of three receptors from dynamic combinatorial libraries of peptide-hydrazonesElectronic supplementary information (ESI) available: NMR and IR data of the Li+ complexes of (mPF)2, (pPF)3 and (pPC)3. See http://www.rsc.org/suppdata/ob/b3/b300956d/Organic & Biomolecular Chemistry, 2003
- Reversed-phase HPLC lignan chiral analysis with laser polarimetric detectionTetrahedron: Asymmetry, 2003
- Recent advances in chiral detection for high performance liquid chromatographyTrAC Trends in Analytical Chemistry, 2001
- Chiral analysis based on polarimetric detectionTrAC Trends in Analytical Chemistry, 1993