An homogeneous population of β1-adrenoceptors subserves inhibitory responses in guinea-pig ileal preparations
- 1 October 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (10), 698-699
- https://doi.org/10.1111/j.2042-7158.1984.tb04849.x
Abstract
In transmurally stimulated guinea-pig ileal preparations, the pA2 values obtained with the selective β1- and β2-adrenoceptor antagonists atenolol and ICI 118,551 were independent of the β-adrenoceptor agonist used ((-)-isoprenaline or fenoterol) and were similar to values reported in isolated cardiac tissue. On the basis of these results, the relaxant responses to β-adrenoceptor agonists in guinea-pig ileal preparations appear to be mediated by an homogeneous population of β1-adrenoceptors.Keywords
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