Delayed functional disability in dystrophic chickens receiving chemotherapy
- 1 January 1979
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 2 (1), 57-67
- https://doi.org/10.1002/mus.880020109
Abstract
Line 413 early-onset, genetically homozygous dystrophic chickens were given twice-daily intraperitoneal injections of the antiserotoninergic drug cinanserin, alone or in combination with methysergide. Other trials consisted of penicillamine treatment in combination with either methysergide or cyproheptadine. Chemotherapy significantly prolonged the righting ability of treated dystrophic chickens, as measured by a periodic standardized fliptest procedure. Plasma creatine kinase activities were not affected by any of the various drug treatments. However, the blood serotonin levels of the dystrophic chickens (grand mean 1.47 μg serotonin/ml blood) were found to be significantly higher (p<0.001) than those in the corresponding normal chickens (0.99 μg/ml). This finding may partially account for the antiserotoninergic drug enhancement in righting ability that was demonstrated in the drug-treated dystrophic chickens.This publication has 30 references indexed in Scilit:
- Therapeutic Trials in Muscular DystrophyArchives of Neurology, 1977
- Assessment of muscle strength in Duchenne muscular dystrophyNeurology, 1977
- Experimental serotonin myopathyNeurology, 1977
- Effects of serotonin antagonists on the development of inherited muscular dystrophy in the chickenExperimental Neurology, 1977
- Serum creatine phosphokinase levels and prednisone treated muscle weaknessNeurology, 1977
- Postponement of symptoms of hereditary muscular dystrophy in chickens by 5-hydroxytryptamine antagonistsNature, 1976
- Serotonin-Induced Muscle WeaknessArchives of Neurology, 1974
- Serotonin and Platelet Function in Duchenne Muscular DystrophyArchives of Neurology, 1973
- Catecholamines and Indoleamines in Patients With Duchenne Muscular DystrophyArchives of Neurology, 1972
- Serotonin Antagonist Increases Longevity in Mice With Hereditary Muscular Dystrophy.Experimental Biology and Medicine, 1967