QUANTITATIVE STUDIES OF NATURALLY OCCURRING MURINE LEUKEMIA VIRUS INFECTION OF AKR MICE
Open Access
- 1 February 1972
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 135 (2), 429-436
- https://doi.org/10.1084/jem.135.2.429
Abstract
Quantitative studies were made of the organ distribution of murine leukemia virus in AKR mice of various ages. Infectious virus first appeared shortly before or after birth and was continuously present in all mice thereafter. Highest infectivity titers were found in uterus and bone, with spleen slightly lower. Virus titers in normal thymus were relatively low, but increased significantly with the development of thymic lymphoma. The level of viremia decreased after the 1st month of life, but increased sharply in lymphomatous mice.Keywords
This publication has 8 references indexed in Scilit:
- A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSESThe Journal of Experimental Medicine, 1971
- Plaque assay techniques for murine leukemia virusesVirology, 1970
- Formation of Virus-like Particles by Bone Cells in Mice with a High Incidence of Spontaneous LeukemiaScience, 1970
- Host-Range Restrictions of Murine Leukemia Viruses in Mouse Embryo Cell CulturesJournal of Virology, 1970
- MIXED CULTURE CYTOPATHOGENICITY: A NEW TEST FOR GROWTH OF MURINE LEUKEMIA VIRUSES IN TISSUE CULTUREProceedings of the National Academy of Sciences, 1969
- Wild-Type Gross Leukemia Virus. I. Soluble Antigen (GSA) in the Plasma and Tissues of Infected Mice2JNCI Journal of the National Cancer Institute, 1968
- The R.I.L. Strain of Mice: Its Relation to the Leukemic AK Strain and AKR SubstrainsJNCI Journal of the National Cancer Institute, 1954
- SPONTANEOUS LEUKEMIA DEVELOPING IN C3H MICE FOLLOWING INOCULATION, IN INFANCY, WITH AK-LEUKEMIC EXTRACTS, OR AK-EMBRYOS1951