Autoradiographic localization of dopamine receptors in the spinal cord of the rat using [3H]-N-propylnorapomorphine
- 1 September 1984
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 59 (3), 251-256
- https://doi.org/10.1007/bf01250012
Abstract
Dopamine receptors were localized autoradiographically in the rat spinal cord afterin vitro labelling using3H-N-propylnorapomorphine (NPA). The highest densities of3H-NPA binding sites were found in the substantia gelatinosa and in a zone of the grey matter immediately ventral to the dorsal corticospinal tract. Other areas of the grey matter presented only moderate or low receptor densities while no3H-NPA binding sites could be found in the white matter. The localization of3H-NPA binding sites is compatible with a role for spinal cord dopamine in the processing of sensory information.Keywords
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