Depressed contractile function in reperfused canine myocardium: metabolism and response to pharmacological agents

Abstract

Regional myocardial function was measured with miniature ultrasonic crystals before, during, and after 10 min of coronary occlusion in anaesthetised open-chest dogs. In normal myocardium, intracoronary isoprenaline (0.1 μg·min⁻¹) increased contraction velocity during the first third of systole (early systolic velocity) from 13.8±2.5 to 19.4±3.9 mm·s⁻¹·cm⁻¹, (P3·min⁻¹·g⁻¹ (P3·min¹·g⁻¹, (P−1·cm⁻¹ (P −1·cm⁻¹ (P 3·min^1-·g⁻¹ (P3·min⁻¹·g⁻¹(P per se, but is consistent with calcium overload during the period of reperfusion.