Antitumor anthracycline antibiotics, aclacinomycin A and analogues. I. Taxonomy, production, isolation and physicochemical properties.

Abstract

Aclacinomycin A and B, 2 major components of a new antitumor antibiotic complex, and their 19 analogs were produced by a culture of strain No. MA144-M1, which was identified as Streptomyces galilaeus. They were isolated by chelation with Cu ion and silicic acid chromatography, and characterized by physicochemical methods in the anthracycline group of antibiotics.